个东谈主简介 夫妻性爱夫妻性爱
张文采,博士,扣问员,博士生导师,南昌大学生物医学改进扣问院副院长,国度级、省级东谈主才。兼任中国生理学会升沉神经科学专科委员会委员,中国神经科学学会应激神经生物学分会委员/副文告,中国神经科学学会麻醉与脑功能学会后生委员,江西省后生科技协会理事/副文告长。连年来扣问后果以第一作家或通信作家身份在Biological Psychiatry,Advanced Materials,Nature Communications,Science Bulletin等期刊发表论文30余篇。论文近5年被引1700余次,单篇最高被引360次(Google Scholar数据),其中1篇论文被Faculty1000列为推选论文,2篇论文入选ESI高被引论文,1篇论文入选热门论文。先后主合手国度当然科学基金优青、面上、后生基金;以及江西省双千技俩、江西省杰青、要点等省部级技俩;行为技俩主干参与科技部紧要技俩(1170万)。获2020年江西省当然科学二等奖(第二完成东谈主)。
扣问标的
诈骗神经示踪、电生理、光纤记载、光遗传学、化学遗传学等前沿践诺技艺,在分子、突触、细胞、环路以及动物举止水对等多个层面融会焦炙症、抑郁症等精神疾病的发病机制,并基于中医药活性要素和纳米载药材料设备相应的疾病防治政策。
代表性论文
1. Wen-Hua Zhang, Jun-Yu Zhang, Andrew Holmes, Bing-Xing Pan*. Amygdala circuit substrates for stress adaptation and adversity. Biological Psychiatry, 2021, 89(9):847-856 (IF2021=12.81),封面著作
2. Wen-Hua Zhang, Wei-Zhu Liu, Ye He, Wen-Jie You, Jun-Yu Zhang, Hong Xu, Xiao-Li Tian, Bao-Ming Li, Lin Mei, Andrew Holmes, Bing-Xing Pan*. Chronic stress causes projection-specific adaptation of amygdala neurons via small-conductance calcium-activated potassium channel downregulation. Biological Psychiatry, 2019, 85(10):812-828 (IF2019=12.09),(Preview by Ming-Hu Han, Biological Psychiatry, 85:784-786, 2019)
3. Zhi-Heng Zheng#, Jiang-Long Tu#, Xiao-Han Li, Qing Hua, Wei-Zhu Liu, Yu Liu, Bing-Xing Pan, Ping Hu, Wen-Hua Zhang*. Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala. Brain Behavior and Immunity, 2021, 91:505-518. (IF2021=19.23), ESI群众1‰热门论文,1%高被引论文
4. Yu Liu#, Ping Hu#, Zhi-Heng Zheng, Da Zhong, Wei-Chang Xie, Zhi-Bo Tang, Bing-Xing Pan*, Jun Luo*, Wen-Hua Zhang*, Xiao-Lei Wang*. Photoresponsive Vaccine-Like CAR-M System with High- Efficiency Central Immune Regulation for Inflammation-related Depression. Advanced Materials, 2022, 34(11):e2108525. (IF2022=29.4)
5. Xia Qin夫妻性爱, Han-Qing Pan, Shou-He Huang, Jia-Xin Zou, Zhi-Heng Zheng, Xiao-Xuan Liu, Wen-Jie You, Zhi-Peng Liu, Jun-Li Cao, Wen-Hua Zhang*, Bing-Xing Pan*. GABAA(δ) receptor hypofunction in the amygdala-hippocampal circuit underlies stress-induced anxiety. Science Bulletin, 2022, 67(1):97-110 (IF2022=18.9)
6. Wei-Zhu Liu#, Wen-Hua Zhang#, Zhi-Heng Zheng, Jia-Xin Zou, Xiao-Xuan Liu, Shou-He Huang, Wen-Jie You, Ye He, Jun-Yu Zhang, Xiao-Dong Wang, Bing-Xing Pan*. Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety. Nature Communications, 2020, 11:2221 (IF2020=14.92),Faculty Opinions (原F1000 prime)推选论文,ESI群众1%高被引论文
7. Li-Guo Jin#, Ping Hu#, Yin-Yin Wang, Luo-Jia Wu, Kang Qin, Hao-Xin Cheng, Shu-Hua Wang, Bing-Xing Pan, Hong-Bo Xin, Wen-Hua Zhang*, Xiao-Lei Wang*. Fast-Acting Black-Phosphorus-Assisted Depression Therapy with Low Toxicity. Advanced Materials, 2020, 32(2):e1906050. (IF2020=30.85)
8. Wei-Zhu Liu, Shou-He Huang, Yu Wang, Chun-Yan Wang, Han-Qing Pan, Ke Zhao, Ping Hu, Bing-Xing Pan*, Wen-Hua Zhang*. Medial prefrontal cortex input to basolateral amygdala controls acute stress-induced short-term anxiety-like behavior in mice. Neuropsychopharmacology, 2023, 48:734-744. (IF2022=7.6)
欧美在线9. Wei-Zhu Liu#, Chun-Yan Wang#, Yu Wang, Wei-Xiang Zhong, Mei-Ting Cai, Tian Liu, Zhi-Hao Wang, Han-Qing Pan, Wen-Hua Zhang* and Bing-Xing Pan*. Circuit- and laminar-specific regulation of medial prefrontal neurons by chronic stress. Cell and Bioscience, 2023, 13:90, (IF2022=7.5)
10. Zhi-Heng Zheng#, Xing-Cheng Lin#, Ying Lu, Shi-Rui Cao, Xu-Kai Liu, Dong Lin, Fan-Hua Yang, Yang-Bo Zhang, Jiang-Long Tu, Bing-Xing Pan, Ping Hu*, Wen-Hua Zhang*. Harmine exerts anxiolytic effects by regulating neuroinflammation and neuronal plasticity in the basolateral amygdala. International Immunopharmacology, 2023, 119:110208, (IF2021=5.6)
11. Ping Hu#, Ying Lu#, Bing-Xing Pan*, Wen-Hua Zhang*. New insights into the pivotal role of the amygdala in inflammation-related depression and anxiety disorder. International Journal of Molecular Sciences, 2022, 23(19):11076 (IF2022=5.6), Top Downloaded Papers in 2022
12. Shou-He Huang#, Wei-Zhu Liu#, Xia Qin, Chen-Yi Guo, Qing-Cheng Xiong, Yu Wang, Ping Hu, Bing-Xing Pan*, Wen-Hua Zhang*. Association of increased amygdala activity with stress-induced anxiety but not social avoidance behavior in mice. Neuroscience Bulletin, 2022, 38(1)16-28, (IF2022=5.6)
主合手技俩
1. 国度当然科学基金优秀后生基金,“焦炙神态产生的杏仁核机制”,2023-2025
2. 国度当然科学基金面上技俩,“杏仁核神经元病笃性扼制电流互异化变化在应激致过度焦炙中的作用及机制”,2020-2023
3. 国度当然科学基金后生基金技俩,“Rap1在慢性应激致海马神经元结构和突触功能毁伤中的作用与机制”,17万,2017-2019
4. 江西省国度级高等次东谈主才改进创业技俩,“基于个体互异扣问慢性应激致焦炙拦阻的脑机制”,2023-2026
5. 江西省“双千计较”科技改进高端东谈主才(后生)技俩,基于杏仁核微环路扣问扼制性信号在慢性应激激勉焦炙拦阻的作用,2020-2023
6. 江西省当然科学基金要点技俩,“杏仁核-海马神经环路在慢性应激致过度焦炙中的作用及机制”,2020-2023
7. 江西省当然科学基金了得后生基金技俩,“基于前额叶-杏仁核环路扣问慢性应激激勉焦炙拦阻的机制”,2019-2022
科研获奖及专利
个东谈主荣誉:
1. 2020年江西省当然科学奖,环境因子影响心扉与记念的脑机制,二等奖(名轮番二)
2. 南昌大学后生五四奖章赢得者(2023年)
授权发明专利:
1. 一种高亲和力抗丙型肝炎病毒的全东谈主源单克隆抗体相等用途。发明东谈主:胡萍,辛洪波,尧志峰,刘苏俊,张文采。中国,专利号:ZL202110498647.1
2. 一种高亲和力抗狂犬病病毒的全东谈主源单克隆抗体相等用途。发明东谈主:胡萍,辛洪波,王纯艳,刘苏俊,张文采。中国,专利号:ZL202110498615.1
3. 一种细胞模子相等构建举止和在筛选抗神经叨唠性疾病药物中的应用。发明东谈主:刘剑峰,张文采,孟夏,皮振钧,胡萍,孙兵。中国,专利号:ZL201210394298.X(授权)